![]() 8, 9 Despite the fact that the transformation of chiral structures has been modulated Of proteins may disrupt normal cellular metabolism and increase the risk of some diseases 6, 7 The conformational misfolding or disorders in coiled-coil superhelical structures Replication and transcription of genomes. 4, 5 For instance, decoiling and reforming of DNA superhelixes are the prerequisites for Superhelical structures realize many important biological functions. Β-sheet in proteins) are fundamental units in living systems, 1 – 3 typically because dynamic transitions between lower-order structures and higher-order Study provides an innovative approach to explore the supramolecular assembly-relatedīiological processes by the dynamic variation of the superstructured helix in artificialĬhiral architectures (e.g., double-helical DNA, triple-helical collagen, α-helix and Moreover, the dynamic superhelical fibers as cell culture scaffoldsĬan induce cell release via change of morphology from superhelix to nanospheres. Stereospecific interactions with proteins than primary fibers, facilitating cell adhesionĪnd proliferation. The superhelical fibers mimicking the extracellular matrix exhibit stronger Transition between the superhelix and nanospheres, which is regulated by the redox The coordination between carboxyl moieties and metal ions enables the in situ morphological Stacking under the molecular aggregation state, which combines with hydrogen bondingīetween phenylalanine moieties to contribute to the formation of the superhelix. ![]() The rotary packing of biphenyl central units allows π–π ![]() Herein, a novel biphenylĬentral core symmetrically coupled with phenylalanine groups drives the construction Higher-order superhelical structures (e.g., double-helical DNA, helical biopolymers)Īre of vital importance in many physiological processes, but still remain a greatĬhallenge to be realized in artificially assembled systems. Dynamic transitions of supramolecular assemblies between lower-order structures and ![]()
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